UAC Seminar: Maria Selmer & Diarmaid Hughes

  • Date: –14:00
  • Location: Zoom https://bit.ly/UACmay22
  • Lecturer: Maria Selmer & Diarmaid Hughes
  • Website
  • Organiser: Uppsala Antibiotic Center
  • Contact person: Eva Garmendia
  • Seminarium

Welcome to the UAC seminar series. Over the next occasions we will be presenting the science being done at UAC, featuring the projects and principal investigators that are part of our center.

"Chromosomal Hybrids: A source of globally-spread antibiotic-resistant bacterial pathogens" - Dr. Diarmaid Hughes.

There are several mechanisms through which bacteria may develop resistance to antibiotics. Among the most important ones are the acquisition of resistance genes on plasmids through horizontal genetic transfer, and mutations in chromosomal genes. Recent research suggests an alternative genetic path, namely the transfer of large segments of chromosomal DNA from one bacterium to another,  creating strains with hybrid chromosomes that in a single genetic event may become highly resistant to antibiotics and/or more virulent. Two examples of clinical strains that fit this description are ST1193 (Escherichia coli) and ST258 (Klebsiella pneumoniae). Both are multidrug-resistant, highly virulent, and globally widespread. Each strain is a genetic hybrid with at least 20% (>1 Mb) of its chromosome originating in a separate strain. Currently there is no information on the mechanisms of hybrid formation, on the prevalence of hybrid strains among clinical and natural isolates, or on their general importance for antibiotic resistance. This talk will introduce the background to Talia Berruga-Fernandez’s UAC-sponsored PhD project, including recent data and future plans.

 

"Antibiotic resistance in relation to bacterial protein synthesis - what can we learn using structural biology?" - Dr. Maria Selmer

A large fraction of clinically used antibiotics act as inhibitors of bacterial protein synthesis. I will present examples of how we use structural biology to gain insights into the detailed mechanisms of resistance to these drugs.