Understanding and improving antibiotic prescribing at a tertiary hospital

Antibiotic overuse and misuse is the main driver of emerging crisis of multidrug-resistant bacteria. It has been estimated that as much as 50% of antibiotic prescriptions are inappropriate. Antibiotic interventions to improve prescribing patterns have been successfully implemented in primary care in Sweden and other countries. However, much of the last-resort antibiotics are used in hospitals in which decisions on therapy for bacterial infections are more complex. In this project, we will explore the appropriateness of antibiotic prescribing at Uppsala University Hospital, incentives for prescribing and measures to prevent inappropriate use. Antibiotic interventions will be conducted at selected hospital departments using a multifaceted and cross-disciplinary approach including physician, nurses and clinical pharmacists. We believe that a drastic and sustainable behavioural change in prescribing patterns can be obtained that will enhance the accuracy of prescriptions, reduce the risks of side effects for the individual patients and prevent emergence and spread of multidrug-resistant bacteria. By using a systematic approach to show causative effects of the measures taken the project will provide important new knowledge to this field and can serve as a best practice example for others striving to improve hospital antibiotic prescribing.

Researchers at UU

Related published research

Under construction