New Antibiotics from small molecules

Applying organic chemistry towards the design and synthesis of small molecule probes, here we hope to elucidate how small molecules influence both the host and other bacteria. This includes investigating the molecular mechanisms of colonization resistance, how bacterial toxins inflict their damage upon the host and developing new chemical biology tools to analyse and influence bacterial function. This work will provide new opportunities for antibiotic drug discovery.

UU Researcher

Lindon Moodie

Associate senior lecturer/Assistant Professor at Department of Medicinal Chemistry, Drug Design and Discovery

Email:
lindon.moodie[AT-sign]ilk.uu.se

RELATED PUBLISHED RESEARCH

Antibiotics and Bacterial Infection

  1. Sulfadiazine Masquerading as a Natural Product from Scilla madeirensis (Scilloideae). L. P. Robertson*, L. W. K. Moodie, D. C. Holland, K. C. Jandér and U. Göransson, Journal of Natural Products, 2020, 83 (4), 1305-1308
  2. Photoactivated Colibactin Probes Induce Cellular DNA Damage. L. W. K. Moodie,* M. Hubert, X. Zhou, M. F. Albers, R. Lundmark, S. Wanrooij and C. Hedberg*, Angewandte Chemie International Edition2019, 58, 1417-1421.

Chemical Biology

  1. Lipid accumulation promotes scission of caveolae. M. Hubert, E. Larsson, N. V. G.  Vegesna, M. Ahnlund, A. I. Johansson, L. W. K. Moodie, R. Lundmark*, eLife. e55038
  2. Palladium-Mediated Approach to Coumarin-Functionalized Amino AcidsOrganic Letters, L. W. K. Moodie, S. Chammaa, T. Kindahl and C. Hedberg*, 2017, 19, 2797-2800.
  3. Synthesis and Spectroscopic Properties of Fluorinated Coumarin Lysine Derivatives. L. Shukla, L. W. K. Moodie, T. Kindahl and C. Hedberg*, The Journal of Organic Chemistry, 2018, 83, 4792-4799. Medicinal Chemistry of Natural Products
  4. Natural cholinesterase inhibitors from marine organisms. L. W. K. Moodie, K. Sepčić, T. Turk, R. Frangežc and J. Svenson*, Natural Product Reports2019, 36, 1053-1092. 
  5. Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime HybridsL. W. K. Moodie*, G. Cervin, R. Trepos, C. Labriere, C. Hellio, H. Pavia and J. Svenson, Marine Biotechnology2018, 20, 257-267.
  6. Prevention of Marine Biofouling Using the Natural Allelopathic Compound Batatasin-III and Synthetic AnaloguesL W. K. Moodie, R. Trepos, G. Cervin, K. A. Bråthen, B. Lindgård, R. Reiersen, P. Cahill, H. Pavia, C. Hellio, and J. Svenson*, Journal of Natural Products2017, 80, 2001-2011. 
  7. Probing the Structure–Activity Relationship of the Natural Antifouling Agent Polygodial against both Micro- and Macrofoulers by Semisynthetic ModificationL. W. K. Moodie, R. Trepos, G. Cervin, L. Larsen, D. S. Larsen, H. Pavia, C. Hellio, P. Cahill, and J. Svenson*, Journal of Natural Products2017, 80, 515-525.
  8. Synthetic analogs of stryphnusin isolated from the marine sponge Stryphnus fortis inhibit acetylcholinesterase with no effect on muscle function or neuromuscular transmissionL. W. K. Moodie, M. C. Žužek, R. Frangež, J. H. Andersen, E. Hansen, E. K. Olsen, M. Cergolj, K. Sepčić, K. Ø. Hansen* and J. Svenson*, Organic & Biomolecular Chemistry2016, 14, 11220-11229. 
  9. Marine AChE inhibitors isolated from Geodia barretti: natural compounds and their synthetic analogsE. K. Olsen, E. Hansen, L. W. K. Moodie, J. Isaksson, K. Sepčić, M. Cergolj, J. Svenson* and J. H. Andersen*, Organic & Biomolecular Chemistry2016, 14, 1629-1640.